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| Nasal administration ： ウィキペディア英語版 |
Nasal administration
Nasal administration is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. Nasal sprays are locally acting drugs such as decongestants for cold and allergy treatment, whose systemic effects are usually minimal. Examples of systemically active drugs available as nasal sprays are migraine drugs, nicotine replacement, and hormone treatments.
== Advantages with nasal systemic drug delivery ==
The nasal cavity is covered by a thin mucosa which is well vascularised.〔D.F. Proctor and I. Andersen. The nose. Upper airway physiology and the atmospheric environment, Elsevier Biomedical Press, Amsterdam, 1982.〕 Therefore, a drug molecule can be transferred quickly across the single epithelial cell layer directly to the systemic blood circulation without first-pass hepatic and intestinal metabolism. The effect is often reached within 5 min for smaller drug molecules.〔Y.W. Chien, K.S.E. Su, and S.-F. Chang. Nasal systemic drug delivery, Marcel Dekker, Inc., New York, 1989.〕 Nasal administration can therefore be used as an alternative to oral administration of for example tablets and capsules if a fast effect is desired or if the drug is extensively degraded in the gut or liver.〔http://www.diva-portal.org/diva/getDocument?urn_nbn_se_uu_diva-9292__fulltext.pdf〕 Drugs which show poor absorbtivity can be given by this route.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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